Structural Biology

About Us

Our research is focused on the structure-dynamics-function correlation of globular and membrane proteins.

Below you find some featured articles. To access a searchable database of our publications please use the Biblio link on the left or the Publication tab above.

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Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico.

Submitted by Administrator on October 4, 2013 - 12:32

Tesauro, C.; Morozzo della Rocca, B.; Ottaviani, A.; Coletta, A.; Zuccaro, L.; Arnò, B.; D'Annessa, I.; Fiorani, P.; Desideri, A. Molecular mechanism of the camptothecin resistance of Glu710Gly topoisomerase IB mutant analyzed in vitro and in silico. Mol Cancer 2013, 12, 100.

Role of the protein in the DNA sequence specificity of the cleavage site stabilized by the camptothecin topoisomerase IB inhibitor: a metadynamics study.

Submitted by Administrator on September 5, 2013 - 18:02

Coletta, A.; Desideri, A. Role of the protein in the DNA sequence specificity of the cleavage site stabilized by the camptothecin topoisomerase IB inhibitor: a metadynamics study. Nucleic Acids Res 2013.

Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction.

Submitted by Administrator on April 2, 2013 - 09:26

Mancini, G.; D'Annessa, I.; Coletta, A.; Chillemi, G.; Pommier, Y.; Cushman, M.; Desideri, A. Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction. PLoS One 2012, 7, e51354.

Structural dynamics of V3 loop with different electrostatics: implications on co-receptor recognition: a molecular dynamics study of HIV gp120.

Submitted by Administrator on October 10, 2012 - 10:45

Chandramouli, B.; Chillemi, G.; Giombini, E.; Capobianchi, M. R.; Rozera, G.; Desideri, A. Structural dynamics of V3 loop with different electrostatics: implications on co-receptor recognition: a molecular dynamics study of HIV gp120. J Biomol Struct Dyn 2012.

ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism.

Submitted by Administrator on February 14, 2012 - 17:00

Sengupta, S.; Ganguly, A.; Roy, A.; Bosedasgupta, S.; D'Annessa, I.; Desideri, A.; Majumder, H. K. ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism. Nucleic acids research 2011, 39, 3295-309.

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin.

Submitted by Administrator on February 13, 2012 - 00:04

D'Annessa, I.; Tesauro, C.; Fiorani, P.; Chillemi, G.; Castelli, S.; Vassallo, O.; Capranico, G.; Desideri, A. Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin. Journal of amino acids 2012, 2012, 206083.

The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

Submitted by Administrator on January 19, 2012 - 13:50

Napoli, I.; Mercaldo, V.; Pilo Boyl, P.; Eleuteri, B.; Zalfa, F.; De Rubeis, S.; Di Marino, D.; Mohr, E.; Massimi, M.; Falconi, M.; Witke, W.; Costa-Mattioli, M.; Sonenberg, N.; Achsel, T.; Bagni, C. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 2008, 134, 1042-54.

Deciphering the structural properties that confer stability to a DNA nanocage.

Submitted by Administrator on January 19, 2012 - 13:49

Falconi, M.; Oteri, F.; Chillemi, G.; Andersen, F. F.; Tordrup, D.; Oliveira, C. L. P.; Pedersen, J. S.; Knudsen, B. R.; Desideri, A. Deciphering the structural properties that confer stability to a DNA nanocage. ACS nano 2009, 3, 1813-22.

Read more about Deciphering the structural properties that confer stability to a DNA nanocage.
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Structure of nanoscale truncated octahedral DNA cages: variation of single-stranded linker regions and influence on assembly yields.

Submitted by Administrator on January 19, 2012 - 13:49

Oliveira, C. L. P.; Juul, S.; Jørgensen, H. L.; Knudsen, B.; Tordrup, D.; Oteri, F.; Falconi, M.; Koch, J.; Desideri, A.; Pedersen, J. S.; Andersen, F. F.; Knudsen, B. R. Structure of nanoscale truncated octahedral DNA cages: variation of single-stranded linker regions and influence on assembly yields. ACS nano 2010, 4, 1367-76.

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