Structural Biology

About Us

Our research is focused on the structure-dynamics-function correlation of globular and membrane proteins.

Below you find some featured articles. To access a searchable database of our publications please use the Biblio link on the left or the Publication tab above.

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Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction.

Submitted by Administrator on April 2, 2013 - 09:26

Mancini, G.; D'Annessa, I.; Coletta, A.; Chillemi, G.; Pommier, Y.; Cushman, M.; Desideri, A. Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction. PLoS One 2012, 7, e51354.

Structural dynamics of V3 loop with different electrostatics: implications on co-receptor recognition: a molecular dynamics study of HIV gp120.

Submitted by Administrator on October 10, 2012 - 10:45

Chandramouli, B.; Chillemi, G.; Giombini, E.; Capobianchi, M. R.; Rozera, G.; Desideri, A. Structural dynamics of V3 loop with different electrostatics: implications on co-receptor recognition: a molecular dynamics study of HIV gp120. J Biomol Struct Dyn 2012.

ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism.

Submitted by Administrator on February 14, 2012 - 17:00

Sengupta, S.; Ganguly, A.; Roy, A.; Bosedasgupta, S.; D'Annessa, I.; Desideri, A.; Majumder, H. K. ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism. Nucleic acids research 2011, 39, 3295-309.

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin.

Submitted by Administrator on February 13, 2012 - 00:04

D'Annessa, I.; Tesauro, C.; Fiorani, P.; Chillemi, G.; Castelli, S.; Vassallo, O.; Capranico, G.; Desideri, A. Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin. Journal of amino acids 2012, 2012, 206083.

The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

Submitted by Administrator on January 19, 2012 - 13:50

Napoli, I.; Mercaldo, V.; Pilo Boyl, P.; Eleuteri, B.; Zalfa, F.; De Rubeis, S.; Di Marino, D.; Mohr, E.; Massimi, M.; Falconi, M.; Witke, W.; Costa-Mattioli, M.; Sonenberg, N.; Achsel, T.; Bagni, C. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 2008, 134, 1042-54.

Deciphering the structural properties that confer stability to a DNA nanocage.

Submitted by Administrator on January 19, 2012 - 13:49

Falconi, M.; Oteri, F.; Chillemi, G.; Andersen, F. F.; Tordrup, D.; Oliveira, C. L. P.; Pedersen, J. S.; Knudsen, B. R.; Desideri, A. Deciphering the structural properties that confer stability to a DNA nanocage. ACS nano 2009, 3, 1813-22.

Read more about Deciphering the structural properties that confer stability to a DNA nanocage.
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Structure of nanoscale truncated octahedral DNA cages: variation of single-stranded linker regions and influence on assembly yields.

Submitted by Administrator on January 19, 2012 - 13:49

Oliveira, C. L. P.; Juul, S.; Jørgensen, H. L.; Knudsen, B.; Tordrup, D.; Oteri, F.; Falconi, M.; Koch, J.; Desideri, A.; Pedersen, J. S.; Andersen, F. F.; Knudsen, B. R. Structure of nanoscale truncated octahedral DNA cages: variation of single-stranded linker regions and influence on assembly yields. ACS nano 2010, 4, 1367-76.

Structural Biology

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