2024
Secli, Valerio; Michetti, Emma; Pacello, Francesca; Iacovelli, Federico; Falconi, Mattia; Astolfi, Maria Luisa; Visaggio, Daniela; Visca, Paolo; Ammendola, Serena; Battistoni, Andrea
Investigation of Zur-regulated metal transport systems reveals an unexpected role of pyochelin in zinc homeostasis Journal Article
In: mBio, vol. 15, iss. 10, pp. e02395-24, 2024.
@article{nokey,
title = {Investigation of Zur-regulated metal transport systems reveals an unexpected role of pyochelin in zinc homeostasis},
author = {Valerio Secli and Emma Michetti and Francesca Pacello and Federico Iacovelli and Mattia Falconi and Maria Luisa Astolfi and Daniela Visaggio and Paolo Visca and Serena Ammendola and Andrea Battistoni},
url = {https://journals.asm.org/doi/10.1128/mbio.02395-24},
doi = {https://doi.org/10.1128/mbio.02395-24},
year = {2024},
date = {2024-09-24},
journal = {mBio},
volume = {15},
issue = {10},
pages = {e02395-24},
abstract = {Limiting the availability of transition metals at infection sites serves as a critical defense mechanism employed by the innate immune system to combat microbial infections. Pseudomonas aeruginosa exhibits a remarkable ability to thrive in zinc-deficient environments, facilitated by intricate cellular responses governed by numerous genes regulated by the zinc-responsive transcription factor Zur. Many of these genes have unknown functions, including those within the predicted PA2911-PA2914 and PA4063-PA4066 operons. A structural bioinformatics investigation revealed that PA2911-PA2914 comprises a TonB-dependent outer membrane receptor and inner membrane ABC-permeases responsible for importing metal-chelating molecules, whereas PA4063-PA4066 contains genes encoding a MacB transporter, likely involved in the export of large molecules. Molecular genetics and biochemical experiments, feeding assays, and intracellular metal content measurements support the hypothesis that PA2911-PA2914 and PA4063-PA4066 are engaged in the import and export of the pyochelin-cobalt complex, respectively. Notably, cobalt can reduce zinc demand and promote the growth of P. aeruginosa strains unable to import zinc, highlighting pyochelin-mediated cobalt import as a novel bacterial strategy to counteract zinc deficiency. These results unveil an unexpected role for pyochelin in zinc homeostasis and challenge the traditional view of this metallophore exclusively as an iron transporter.},
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Limiting the availability of transition metals at infection sites serves as a critical defense mechanism employed by the innate immune system to combat microbial infections. Pseudomonas aeruginosa exhibits a remarkable ability to thrive in zinc-deficient environments, facilitated by intricate cellular responses governed by numerous genes regulated by the zinc-responsive transcription factor Zur. Many of these genes have unknown functions, including those within the predicted PA2911-PA2914 and PA4063-PA4066 operons. A structural bioinformatics investigation revealed that PA2911-PA2914 comprises a TonB-dependent outer membrane receptor and inner membrane ABC-permeases responsible for importing metal-chelating molecules, whereas PA4063-PA4066 contains genes encoding a MacB transporter, likely involved in the export of large molecules. Molecular genetics and biochemical experiments, feeding assays, and intracellular metal content measurements support the hypothesis that PA2911-PA2914 and PA4063-PA4066 are engaged in the import and export of the pyochelin-cobalt complex, respectively. Notably, cobalt can reduce zinc demand and promote the growth of P. aeruginosa strains unable to import zinc, highlighting pyochelin-mediated cobalt import as a novel bacterial strategy to counteract zinc deficiency. These results unveil an unexpected role for pyochelin in zinc homeostasis and challenge the traditional view of this metallophore exclusively as an iron transporter.
Pietrafesa, Davide; Napoli, Alessandro; Iacovelli, Federico; Romeo, Alice; Tucci, Fabio Giovanni; Billi, Daniela; Falconi, Mattia
Deciphering the Role of Trehalose in Chroococcidiopsis sp. 029’s High-Desiccation Resistance: Sequence Determination, Structural Modelling and Simulative Analysis of the 30S Ribosomal Subunit Journal Article
In: Molecules, vol. 29, iss. 15, pp. 3486, 2024.
@article{nokey,
title = {Deciphering the Role of Trehalose in Chroococcidiopsis sp. 029’s High-Desiccation Resistance: Sequence Determination, Structural Modelling and Simulative Analysis of the 30S Ribosomal Subunit},
author = {Davide Pietrafesa and Alessandro Napoli and Federico Iacovelli and Alice Romeo and Fabio Giovanni Tucci and Daniela Billi and Mattia Falconi},
editor = {Molecules},
url = {https://www.mdpi.com/1420-3049/29/15/3486},
doi = {10.3390/molecules29153486},
year = {2024},
date = {2024-07-25},
urldate = {2024-07-25},
journal = {Molecules},
volume = {29},
issue = {15},
pages = {3486},
publisher = {MDPI},
abstract = {Desert strains of the genus Chroococcidiopsis are among the most desiccation-resistant cyanobacteria capable of anhydrobiosis. The accumulation of two sugars, sucrose and trehalose, facilitates the entrance of anhydrobiotes into a reversible state of dormancy by stabilizing cellular components upon water removal. This study aimed to evaluate, at the atomistic level, the role of trehalose in desiccation resistance by using as a model system the 30S ribosomal subunit of the desert cyanobacterium Chroococcidiopsis sp. 029. Molecular dynamic simulations provided atomistic evidence regarding its protective role on the 30S molecular structure. Trehalose forms an enveloping shell around the ribosomal subunit and stabilizes the structures through a network of direct interactions. The simulation confirmed that trehalose actively interacts with the 30S ribosomal subunit and that, by replacing water molecules, it ensures ribosomal structural integrity during desiccation, thus enabling protein synthesis to be carried out upon rehydration.},
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pubstate = {published},
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Desert strains of the genus Chroococcidiopsis are among the most desiccation-resistant cyanobacteria capable of anhydrobiosis. The accumulation of two sugars, sucrose and trehalose, facilitates the entrance of anhydrobiotes into a reversible state of dormancy by stabilizing cellular components upon water removal. This study aimed to evaluate, at the atomistic level, the role of trehalose in desiccation resistance by using as a model system the 30S ribosomal subunit of the desert cyanobacterium Chroococcidiopsis sp. 029. Molecular dynamic simulations provided atomistic evidence regarding its protective role on the 30S molecular structure. Trehalose forms an enveloping shell around the ribosomal subunit and stabilizes the structures through a network of direct interactions. The simulation confirmed that trehalose actively interacts with the 30S ribosomal subunit and that, by replacing water molecules, it ensures ribosomal structural integrity during desiccation, thus enabling protein synthesis to be carried out upon rehydration.
Ceci, Claudia; Ruffini, Federica; Falconi, Mattia; Atzori, Maria Grazia; Falzon, Andrea; Lozzi, Flavia; Iacovelli, Federico; D'Atri, Stefania; Graziani, Grazia; Lacal, Pedro Miguel
Pharmacological inhibition of PDGF-C/neuropilin-1 interaction: A novel strategy to reduce melanoma metastatic potential Journal Article
In: Biomedicine & Pharmacotherapy, vol. 176, pp. 116766, 2024.
@article{nokey,
title = {Pharmacological inhibition of PDGF-C/neuropilin-1 interaction: A novel strategy to reduce melanoma metastatic potential},
author = {Claudia Ceci and Federica Ruffini and Mattia Falconi and Maria Grazia Atzori and Andrea Falzon and Flavia Lozzi and Federico Iacovelli and Stefania D'Atri and Grazia Graziani and Pedro Miguel Lacal},
editor = {Biomedicine & Pharmacotherapy},
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doi = {10.1016/j.biopha.2024.116766},
year = {2024},
date = {2024-05-23},
journal = {Biomedicine & Pharmacotherapy},
volume = {176},
pages = {116766},
abstract = {Activation of neuropilin-1 (NRP-1) by platelet derived growth factor (PDGF)-C sustains melanoma invasiveness. Therefore, in the search of novel agents capable of reducing melanoma spreading, PDGF-C/NRP-1 interaction was investigated as a potential druggable target. Since the PDGF-C region involved in NRP-1 binding is not yet known, based on the sequence and structural homology between PDGF-C and vascular endothelial growth factor-A (VEGF-A), we hypothesized that the NRP-1 b1 domain region involved in the interaction with VEGF-A might also be required for PDGF-C binding. Hence, this region was selected from the protein crystal structure and used as target in the molecular docking procedure. In the following virtual screening, compounds from a DrugBank database were used as query ligands to identify agents potentially capable of disrupting NRP-1/PDGF-C interaction. Among the top 45 candidates with the highest affinity, five drugs were selected based on the safety profile, lack of hormonal effects, and current availability in the market: the antipsychotic pimozide, antidiabetic gliclazide, antiallergic cromolyn sodium, anticancer tyrosine kinase inhibitor entrectinib, and antihistamine azelastine. Analysis of drug influence on PDGF-C in vitro binding to NRP-1 and PDGF-C induced migration of human melanoma cells expressing NRP-1, indicated gliclazide and entrectinib as the most specific agents that were active at clinically achievable and non-toxic concentrations. Both drugs also reverted PDGF-C ability to stimulate extracellular matrix invasion by melanoma cells resistant to BRAF inhibitors. The inhibitory effect on tumor cell motility involved a decrease of p130Cas phosphorylation, a signal transduction pathway activated by PDGF-C-mediated stimulation of NRP-1.},
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Activation of neuropilin-1 (NRP-1) by platelet derived growth factor (PDGF)-C sustains melanoma invasiveness. Therefore, in the search of novel agents capable of reducing melanoma spreading, PDGF-C/NRP-1 interaction was investigated as a potential druggable target. Since the PDGF-C region involved in NRP-1 binding is not yet known, based on the sequence and structural homology between PDGF-C and vascular endothelial growth factor-A (VEGF-A), we hypothesized that the NRP-1 b1 domain region involved in the interaction with VEGF-A might also be required for PDGF-C binding. Hence, this region was selected from the protein crystal structure and used as target in the molecular docking procedure. In the following virtual screening, compounds from a DrugBank database were used as query ligands to identify agents potentially capable of disrupting NRP-1/PDGF-C interaction. Among the top 45 candidates with the highest affinity, five drugs were selected based on the safety profile, lack of hormonal effects, and current availability in the market: the antipsychotic pimozide, antidiabetic gliclazide, antiallergic cromolyn sodium, anticancer tyrosine kinase inhibitor entrectinib, and antihistamine azelastine. Analysis of drug influence on PDGF-C in vitro binding to NRP-1 and PDGF-C induced migration of human melanoma cells expressing NRP-1, indicated gliclazide and entrectinib as the most specific agents that were active at clinically achievable and non-toxic concentrations. Both drugs also reverted PDGF-C ability to stimulate extracellular matrix invasion by melanoma cells resistant to BRAF inhibitors. The inhibitory effect on tumor cell motility involved a decrease of p130Cas phosphorylation, a signal transduction pathway activated by PDGF-C-mediated stimulation of NRP-1.
Romeo, Alice; Cappelli, Giulia; Iacovelli, Federico; Colizzi, Vittorio; Falconi, Mattia
Computational and experimental validation of phthalocyanine and hypericin as effective SARS-CoV-2 fusion inhibitors Journal Article
In: Journal of Biomolecular Structure and Dynamics, vol. 42, no 8, pp. 3920 – 3934, 2024, (Cited by: 0).
@article{Romeo20243920,
title = {Computational and experimental validation of phthalocyanine and hypericin as effective SARS-CoV-2 fusion inhibitors},
author = {Alice Romeo and Giulia Cappelli and Federico Iacovelli and Vittorio Colizzi and Mattia Falconi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85160793020&doi=10.1080%2f07391102.2023.2216276&partnerID=40&md5=7ab552a31bcff9dcc4bb9a0b8931c5e3},
doi = {10.1080/07391102.2023.2216276},
year = {2024},
date = {2024-01-01},
journal = {Journal of Biomolecular Structure and Dynamics},
volume = {42},
number = {8},
pages = {3920 – 3934},
note = {Cited by: 0},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Tolve, Livia; Iannucci, Alessio; Garofalo, Luisa; Ninni, Andrea; Dondona, Andrea Capobianco; Ceciarini, Ilaria; Cocumelli, Cristiano; Lucia, Alessandra De; Falconi, Mattia; Formia, Angela; Iacovelli, Federico; Mancusi, Cecilia; Marchiori, Erica; Marsili, Letizia; Mingozzi, Toni; Nannarelli, Stefano; Natali, Chiara; Terracciano, Giuliana; Zuffi, Marco A. L.; Novelletto, Andrea; Ciofi, Claudio
Whole mitochondrial genome sequencing provides new insights into the phylogeography of loggerhead turtles (Caretta caretta) in the Mediterranean Sea Journal Article
In: Marine Biology, vol. 171, no 1, 2024, (Cited by: 2; All Open Access, Hybrid Gold Open Access).
@article{Tolve2024,
title = {Whole mitochondrial genome sequencing provides new insights into the phylogeography of loggerhead turtles (Caretta caretta) in the Mediterranean Sea},
author = {Livia Tolve and Alessio Iannucci and Luisa Garofalo and Andrea Ninni and Andrea Capobianco Dondona and Ilaria Ceciarini and Cristiano Cocumelli and Alessandra De Lucia and Mattia Falconi and Angela Formia and Federico Iacovelli and Cecilia Mancusi and Erica Marchiori and Letizia Marsili and Toni Mingozzi and Stefano Nannarelli and Chiara Natali and Giuliana Terracciano and Marco A. L. Zuffi and Andrea Novelletto and Claudio Ciofi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85177670292&doi=10.1007%2fs00227-023-04325-x&partnerID=40&md5=53b26cca64599519b4b637bc167b88d7},
doi = {10.1007/s00227-023-04325-x},
year = {2024},
date = {2024-01-01},
journal = {Marine Biology},
volume = {171},
number = {1},
note = {Cited by: 2; All Open Access, Hybrid Gold Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
2023
Iacovelli, Federico; Romeo, Alice; Lattanzio, Patrizio; Ammendola, Serena; Battistoni, Andrea; Frazia, Simone La; Vindigni, Giulia; Unida, Valeria; Biocca, Silvia; Gaziano, Roberta; Divizia, Maurizio; Falconi, Mattia
Deciphering the Broad Antimicrobial Activity of Melaleuca alternifolia Tea Tree Oil by Combining Experimental and Computational Investigations Journal Article
In: International Journal of Molecular Sciences, vol. 24, no 15, 2023, (Cited by: 0; All Open Access, Gold Open Access, Green Open Access).
@article{Iacovelli2023,
title = {Deciphering the Broad Antimicrobial Activity of Melaleuca alternifolia Tea Tree Oil by Combining Experimental and Computational Investigations},
author = {Federico Iacovelli and Alice Romeo and Patrizio Lattanzio and Serena Ammendola and Andrea Battistoni and Simone La Frazia and Giulia Vindigni and Valeria Unida and Silvia Biocca and Roberta Gaziano and Maurizio Divizia and Mattia Falconi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85167895656&doi=10.3390%2fijms241512432&partnerID=40&md5=2b61f40e63093905d3695cd11d3a4580},
doi = {10.3390/ijms241512432},
year = {2023},
date = {2023-01-01},
journal = {International Journal of Molecular Sciences},
volume = {24},
number = {15},
note = {Cited by: 0; All Open Access, Gold Open Access, Green Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Romeo, Alice; Pellegrini, Roberto; Gualtieri, Maurizio; Benassi, Barbara; Santoro, Massimo; Iacovelli, Federico; Stracquadanio, Milena; Falconi, Mattia; Marino, Carmela; Zanini, Gabriele; Arcangeli, Caterina
Experimental and in silico evaluations of the possible molecular interaction between airborne particulate matter and SARS-CoV-2 Journal Article
In: Science of the Total Environment, vol. 895, 2023, (Cited by: 2; All Open Access, Green Open Access, Hybrid Gold Open Access).
@article{Romeo2023,
title = {Experimental and in silico evaluations of the possible molecular interaction between airborne particulate matter and SARS-CoV-2},
author = {Alice Romeo and Roberto Pellegrini and Maurizio Gualtieri and Barbara Benassi and Massimo Santoro and Federico Iacovelli and Milena Stracquadanio and Mattia Falconi and Carmela Marino and Gabriele Zanini and Caterina Arcangeli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85163832520&doi=10.1016%2fj.scitotenv.2023.165059&partnerID=40&md5=6af3bd9469d75c4f87899abf30c1cd4a},
doi = {10.1016/j.scitotenv.2023.165059},
year = {2023},
date = {2023-01-01},
journal = {Science of the Total Environment},
volume = {895},
note = {Cited by: 2; All Open Access, Green Open Access, Hybrid Gold Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Cosio, Terenzio; Costanza, Gaetana; Coniglione, Filadelfo; Romeo, Alice; Iacovelli, Federico; Diluvio, Laura; Dika, Emi; Shumak, Ruslana Gaeta; Rossi, Piero; Bianchi, Luca; Falconi, Mattia; Campione, Elena
From In Silico Simulation between TGF-β Receptors and Quercetin to Clinical Insight of a Medical Device Containing Allium cepa: Its Efficacy and Tolerability on Post-Surgical Scars Journal Article
In: Life, vol. 13, no 8, 2023, (Cited by: 0; All Open Access, Gold Open Access, Green Open Access).
@article{Cosio2023,
title = {From In Silico Simulation between TGF-β Receptors and Quercetin to Clinical Insight of a Medical Device Containing Allium cepa: Its Efficacy and Tolerability on Post-Surgical Scars},
author = {Terenzio Cosio and Gaetana Costanza and Filadelfo Coniglione and Alice Romeo and Federico Iacovelli and Laura Diluvio and Emi Dika and Ruslana Gaeta Shumak and Piero Rossi and Luca Bianchi and Mattia Falconi and Elena Campione},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85169021028&doi=10.3390%2flife13081781&partnerID=40&md5=fe77a024cc6397e81fa53d52a1c42b77},
doi = {10.3390/life13081781},
year = {2023},
date = {2023-01-01},
journal = {Life},
volume = {13},
number = {8},
note = {Cited by: 0; All Open Access, Gold Open Access, Green Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Campione, Elena; Rivieccio, Antonia; Shumak, Ruslana Gaeta; Costanza, Gaetana; Cosio, Terenzio; Lambiase, Sara; Garofalo, Virginia; Artosi, Fabio; Lozzi, Flavia; Freni, Claudia; Romeo, Alice; Dika, Emi; Falconi, Mattia; Bianchi, Luca
Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses Journal Article
In: Pharmaceuticals, vol. 16, no 12, 2023, (Cited by: 2; All Open Access, Gold Open Access).
@article{Campione2023,
title = {Preliminary Evidence of Efficacy, Safety, and Treatment Satisfaction with Tirbanibulin 1% Ointment: A Clinical Perspective on Actinic Keratoses},
author = {Elena Campione and Antonia Rivieccio and Ruslana Gaeta Shumak and Gaetana Costanza and Terenzio Cosio and Sara Lambiase and Virginia Garofalo and Fabio Artosi and Flavia Lozzi and Claudia Freni and Alice Romeo and Emi Dika and Mattia Falconi and Luca Bianchi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85180676231&doi=10.3390%2fph16121686&partnerID=40&md5=cf66574b52f7b7f50d7e0d84ecf6e13e},
doi = {10.3390/ph16121686},
year = {2023},
date = {2023-01-01},
journal = {Pharmaceuticals},
volume = {16},
number = {12},
note = {Cited by: 2; All Open Access, Gold Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Unida, Valeria; Mangano, Eleonora; Camboni, Tania; Consolandi, Clarissa; Desideri, Alessandro; Severgnini, Marco; Cifola, Ingrid; Biocca, Silvia
Insights on the molecular mechanisms of cytotoxicity induced by AS1411 linked to folate-functionalized DNA nanocages in cancer cells Journal Article
In: Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 54, 2023, (Cited by: 0; All Open Access, Hybrid Gold Open Access).
@article{Unida2023,
title = {Insights on the molecular mechanisms of cytotoxicity induced by AS1411 linked to folate-functionalized DNA nanocages in cancer cells},
author = {Valeria Unida and Eleonora Mangano and Tania Camboni and Clarissa Consolandi and Alessandro Desideri and Marco Severgnini and Ingrid Cifola and Silvia Biocca},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171540293&doi=10.1016%2fj.nano.2023.102710&partnerID=40&md5=bbe3639493e8d2aa7afdabd7cc5c3d1d},
doi = {10.1016/j.nano.2023.102710},
year = {2023},
date = {2023-01-01},
journal = {Nanomedicine: Nanotechnology, Biology, and Medicine},
volume = {54},
note = {Cited by: 0; All Open Access, Hybrid Gold Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Desideri, Alessandro
Meet the Editorial Board Member Journal Article
In: Anti-Cancer Agents in Medicinal Chemistry, vol. 23, no 16, pp. 1795, 2023, (Cited by: 0).
@article{Desideri20231795,
title = {Meet the Editorial Board Member},
author = {Alessandro Desideri},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171428134&doi=10.2174%2f187152062316230811130058&partnerID=40&md5=30bc8be3c97186a146625e3cb7d9439c},
doi = {10.2174/187152062316230811130058},
year = {2023},
date = {2023-01-01},
journal = {Anti-Cancer Agents in Medicinal Chemistry},
volume = {23},
number = {16},
pages = {1795},
note = {Cited by: 0},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Kleine Bardenhorst, Sven; Cereda, Emanuele; Severgnini, Marco; Barichella, Michela; Pezzoli, Gianni; Keshavarzian, Ali; Desideri, Alessandro; Pietrucci, Daniele; Aho, Velma T. E.; Scheperjans, Filip; Hildebrand, Falk; Weis, Severin; Egert, Markus; Karch, André; Vital, Marius; Rübsamen, Nicole
Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis Journal Article
In: European Journal of Neurology, vol. 30, no 11, pp. 3581 – 3594, 2023, (Cited by: 10; All Open Access, Hybrid Gold Open Access).
@article{Kleine Bardenhorst20233581,
title = {Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis},
author = {Sven Kleine Bardenhorst and Emanuele Cereda and Marco Severgnini and Michela Barichella and Gianni Pezzoli and Ali Keshavarzian and Alessandro Desideri and Daniele Pietrucci and Velma T. E. Aho and Filip Scheperjans and Falk Hildebrand and Severin Weis and Markus Egert and André Karch and Marius Vital and Nicole Rübsamen},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146482490&doi=10.1111%2fene.15671&partnerID=40&md5=b12490ee2cfcfabfd58ae7dac4d33163},
doi = {10.1111/ene.15671},
year = {2023},
date = {2023-01-01},
journal = {European Journal of Neurology},
volume = {30},
number = {11},
pages = {3581 – 3594},
note = {Cited by: 10; All Open Access, Hybrid Gold Open Access},
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pubstate = {published},
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Villani, Valentina; Marco, Gabriele Di; Iacovelli, Federico; Pietrucci, Daniele; Canini, Antonella; Gismondi, Angelo
Profile and potential bioactivity of the miRNome and metabolome expressed in Malva sylvestris L. leaf and flower Journal Article
In: BMC Plant Biology, vol. 23, no 1, 2023, (Cited by: 5; All Open Access, Gold Open Access).
@article{Villani2023,
title = {Profile and potential bioactivity of the miRNome and metabolome expressed in Malva sylvestris L. leaf and flower},
author = {Valentina Villani and Gabriele Di Marco and Federico Iacovelli and Daniele Pietrucci and Antonella Canini and Angelo Gismondi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85171665892&doi=10.1186%2fs12870-023-04434-1&partnerID=40&md5=b7042145c84075343670b74cc10df9d0},
doi = {10.1186/s12870-023-04434-1},
year = {2023},
date = {2023-01-01},
journal = {BMC Plant Biology},
volume = {23},
number = {1},
note = {Cited by: 5; All Open Access, Gold Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
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2022
Cutone, Antimo; Rosa, Luigi; Patti, Maria Carmela Bonaccorsi di; Iacovelli, Federico; Conte, Maria Pia; Ianiro, Giusi; Romeo, Alice; Campione, Elena; Bianchi, Luca; Valenti, Piera; Falconi, Mattia; Musci, Giovanni
Lactoferrin Binding to SARS-CoV-2 Spike Glycoprotein Blocks Pseudoviral Entry and Relieves Iron Protein Dysregulation in Several In Vitro Models Journal Article
In: Pharmaceutics, vol. 14, no 10, 2022, (Cited by: 10; All Open Access, Gold Open Access).
@article{Cutone2022,
title = {Lactoferrin Binding to SARS-CoV-2 Spike Glycoprotein Blocks Pseudoviral Entry and Relieves Iron Protein Dysregulation in Several In Vitro Models},
author = {Antimo Cutone and Luigi Rosa and Maria Carmela Bonaccorsi di Patti and Federico Iacovelli and Maria Pia Conte and Giusi Ianiro and Alice Romeo and Elena Campione and Luca Bianchi and Piera Valenti and Mattia Falconi and Giovanni Musci},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140989670&doi=10.3390%2fpharmaceutics14102111&partnerID=40&md5=6f4690b75c3f24dd3237a76447e71d5d},
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year = {2022},
date = {2022-01-01},
journal = {Pharmaceutics},
volume = {14},
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tppubtype = {article}
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Romeo, Alice; Iacovelli, Federico; Scagnolari, Carolina; Scordio, Mirko; Frasca, Federica; Condò, Roberta; Ammendola, Serena; Gaziano, Roberta; Anselmi, Maurizio; Divizia, Maurizio; Falconi, Mattia
Potential Use of Tea Tree Oil as a Disinfectant Agent against Coronaviruses: A Combined Experimental and Simulation Study Journal Article
In: Molecules, vol. 27, no 12, 2022, (Cited by: 13; All Open Access, Gold Open Access, Green Open Access).
@article{Romeo2022,
title = {Potential Use of Tea Tree Oil as a Disinfectant Agent against Coronaviruses: A Combined Experimental and Simulation Study},
author = {Alice Romeo and Federico Iacovelli and Carolina Scagnolari and Mirko Scordio and Federica Frasca and Roberta Condò and Serena Ammendola and Roberta Gaziano and Maurizio Anselmi and Maurizio Divizia and Mattia Falconi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85131671837&doi=10.3390%2fmolecules27123786&partnerID=40&md5=7bffd0d17c3fab801e9e61684249ee0a},
doi = {10.3390/molecules27123786},
year = {2022},
date = {2022-01-01},
journal = {Molecules},
volume = {27},
number = {12},
note = {Cited by: 13; All Open Access, Gold Open Access, Green Open Access},
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pubstate = {published},
tppubtype = {article}
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Iacovelli, Federico; Costanza, Gaetana; Romeo, Alice; Cosio, Terenzio; Lanna, Caterina; Bagnulo, Antonino; Maio, Umberto Di; Sbardella, Alice; Gaziano, Roberta; Grelli, Sandro; Squillaci, Ettore; Miani, Alessandro; Piscitelli, Prisco; Bianchi, Luca; Falconi, Mattia; Campione, Elena
Interaction of Pelargonium sidoides Compounds with Lactoferrin and SARS-CoV-2: Insights from Molecular Simulations Journal Article
In: International Journal of Environmental Research and Public Health, vol. 19, no 9, 2022, (Cited by: 5; All Open Access, Gold Open Access).
@article{Iacovelli2022,
title = {Interaction of Pelargonium sidoides Compounds with Lactoferrin and SARS-CoV-2: Insights from Molecular Simulations},
author = {Federico Iacovelli and Gaetana Costanza and Alice Romeo and Terenzio Cosio and Caterina Lanna and Antonino Bagnulo and Umberto Di Maio and Alice Sbardella and Roberta Gaziano and Sandro Grelli and Ettore Squillaci and Alessandro Miani and Prisco Piscitelli and Luca Bianchi and Mattia Falconi and Elena Campione},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128784585&doi=10.3390%2fijerph19095254&partnerID=40&md5=02550945207bb8e767c90572f27e474f},
doi = {10.3390/ijerph19095254},
year = {2022},
date = {2022-01-01},
journal = {International Journal of Environmental Research and Public Health},
volume = {19},
number = {9},
note = {Cited by: 5; All Open Access, Gold Open Access},
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pubstate = {published},
tppubtype = {article}
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Pietrucci, Daniele; Teofani, Adelaide; Milanesi, Marco; Fosso, Bruno; Putignani, Lorenza; Messina, Francesco; Pesole, Graziano; Desideri, Alessandro; Chillemi, Giovanni
Machine Learning Data Analysis Highlights the Role of Parasutterella and Alloprevotella in Autism Spectrum Disorders Journal Article
In: Biomedicines, vol. 10, no 8, 2022, (Cited by: 11; All Open Access, Gold Open Access, Green Open Access).
@article{Pietrucci2022,
title = {Machine Learning Data Analysis Highlights the Role of Parasutterella and Alloprevotella in Autism Spectrum Disorders},
author = {Daniele Pietrucci and Adelaide Teofani and Marco Milanesi and Bruno Fosso and Lorenza Putignani and Francesco Messina and Graziano Pesole and Alessandro Desideri and Giovanni Chillemi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137375502&doi=10.3390%2fbiomedicines10082028&partnerID=40&md5=a9159761f0e5b74c29ead99a777c27fc},
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year = {2022},
date = {2022-01-01},
journal = {Biomedicines},
volume = {10},
number = {8},
note = {Cited by: 11; All Open Access, Gold Open Access, Green Open Access},
keywords = {},
pubstate = {published},
tppubtype = {article}
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Unida, Valeria; Vindigni, Giulia; Raniolo, Sofia; Stolfi, Carmine; Desideri, Alessandro; Biocca, Silvia
Folate-Functionalization Enhances Cytotoxicity of Multivalent DNA Nanocages on Triple-Negative Breast Cancer Cells Journal Article
In: Pharmaceutics, vol. 14, no 12, 2022, (Cited by: 2; All Open Access, Gold Open Access).
@article{Unida2022,
title = {Folate-Functionalization Enhances Cytotoxicity of Multivalent DNA Nanocages on Triple-Negative Breast Cancer Cells},
author = {Valeria Unida and Giulia Vindigni and Sofia Raniolo and Carmine Stolfi and Alessandro Desideri and Silvia Biocca},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85144863597&doi=10.3390%2fpharmaceutics14122610&partnerID=40&md5=8fff43c1e4a511febdc081ecdf329a63},
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year = {2022},
date = {2022-01-01},
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Laudisi, Federica; Stolfi, Carmine; Bevivino, Gerolamo; Maresca, Claudia; Franzè, Eleonora; Troncone, Edoardo; Lolli, Elisabetta; Marafini, Irene; Pietrucci, Daniele; Teofani, Adelaide; Grazia, Antonio Di; Fusco, Davide Di; Colantoni, Alfredo; Ortenzi, Angela; Desideri, Alessandro; Monteleone, Ivan; Monteleone, Giovanni
GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation Journal Article
In: Journal of Crohn's and Colitis, vol. 16, no 2, pp. 301 – 311, 2022, (Cited by: 14).
@article{Laudisi2022301,
title = {GATA6 Deficiency Leads to Epithelial Barrier Dysfunction and Enhances Susceptibility to Gut Inflammation},
author = {Federica Laudisi and Carmine Stolfi and Gerolamo Bevivino and Claudia Maresca and Eleonora Franzè and Edoardo Troncone and Elisabetta Lolli and Irene Marafini and Daniele Pietrucci and Adelaide Teofani and Antonio Di Grazia and Davide Di Fusco and Alfredo Colantoni and Angela Ortenzi and Alessandro Desideri and Ivan Monteleone and Giovanni Monteleone},
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Teofani, Adelaide; Marafini, Irene; Laudisi, Federica; Pietrucci, Daniele; Salvatori, Silvia; Unida, Valeria; Biocca, Silvia; Monteleone, Giovanni; Desideri, Alessandro
Intestinal Taxa Abundance and Diversity in Inflammatory Bowel Disease Patients: An Analysis including Covariates and Confounders Journal Article
In: Nutrients, vol. 14, no 2, 2022, (Cited by: 21; All Open Access, Gold Open Access).
@article{Teofani2022,
title = {Intestinal Taxa Abundance and Diversity in Inflammatory Bowel Disease Patients: An Analysis including Covariates and Confounders},
author = {Adelaide Teofani and Irene Marafini and Federica Laudisi and Daniele Pietrucci and Silvia Salvatori and Valeria Unida and Silvia Biocca and Giovanni Monteleone and Alessandro Desideri},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122294303&doi=10.3390%2fnu14020260&partnerID=40&md5=1849d23fcb88232373dc15c1986b45bc},
doi = {10.3390/nu14020260},
year = {2022},
date = {2022-01-01},
journal = {Nutrients},
volume = {14},
number = {2},
note = {Cited by: 21; All Open Access, Gold Open Access},
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Falconi, Mattia; Olds, James Leland; Ramanathan, Arvind
Editorial: Interaction of Biomolecules and Bioactive Compounds With the SARS-CoV-2 Proteins: Molecular Simulations for the Fight Against Covid-19 Journal Article
In: Frontiers in Molecular Biosciences, vol. 9, 2022, (Cited by: 0; All Open Access, Gold Open Access, Green Open Access).
@article{Falconi2022,
title = {Editorial: Interaction of Biomolecules and Bioactive Compounds With the SARS-CoV-2 Proteins: Molecular Simulations for the Fight Against Covid-19},
author = {Mattia Falconi and James Leland Olds and Arvind Ramanathan},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133744038&doi=10.3389%2ffmolb.2022.950891&partnerID=40&md5=742b86528662ebdb552577f9bf64c53b},
doi = {10.3389/fmolb.2022.950891},
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date = {2022-01-01},
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Ottaviani, Alessio; Welsch, Joshua; Agama, Keli; Pommier, Yves; Desideri, Alessandro; Baker, Bill J.; Fiorani, Paola
From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica Journal Article
In: Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 37, no 1, pp. 1404 – 1410, 2022, (Cited by: 5; All Open Access, Gold Open Access, Green Open Access).
@article{Ottaviani20221404,
title = {From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica},
author = {Alessio Ottaviani and Joshua Welsch and Keli Agama and Yves Pommier and Alessandro Desideri and Bill J. Baker and Paola Fiorani},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130689793&doi=10.1080%2f14756366.2022.2078320&partnerID=40&md5=31c968b4c14974fb4f8c723f79976aa6},
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pages = {1404 – 1410},
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Mecocci, Samanta; Ottaviani, Alessio; Razzuoli, Elisabetta; Fiorani, Paola; Pietrucci, Daniele; Ciucis, Chiara Grazia De; Giudici, Silvia Dei; Franzoni, Giulia; Chillemi, Giovanni; Cappelli, Katia
Cow Milk Extracellular Vesicle Effects on an In Vitro Model of Intestinal Inflammation Journal Article
In: Biomedicines, vol. 10, no 3, 2022, (Cited by: 18; All Open Access, Gold Open Access, Green Open Access).
@article{Mecocci2022,
title = {Cow Milk Extracellular Vesicle Effects on an In Vitro Model of Intestinal Inflammation},
author = {Samanta Mecocci and Alessio Ottaviani and Elisabetta Razzuoli and Paola Fiorani and Daniele Pietrucci and Chiara Grazia De Ciucis and Silvia Dei Giudici and Giulia Franzoni and Giovanni Chillemi and Katia Cappelli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126044037&doi=10.3390%2fbiomedicines10030570&partnerID=40&md5=7ef0086c8b5b73eaf5f8a6ce892cec6c},
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year = {2022},
date = {2022-01-01},
journal = {Biomedicines},
volume = {10},
number = {3},
note = {Cited by: 18; All Open Access, Gold Open Access, Green Open Access},
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pubstate = {published},
tppubtype = {article}
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Ottaviani, Alessio; Iacovelli, Federico; Welsch, Joshua; Rocca, Blasco Morozzo della; Desideri, Alessandro; Falconi, Mattia; Calcul, Laurent; Baker, Bill J.; Fiorani, Paola
Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B Journal Article
In: Cells, vol. 11, no 21, 2022, (Cited by: 0; All Open Access, Gold Open Access).
@article{Ottaviani2022,
title = {Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B},
author = {Alessio Ottaviani and Federico Iacovelli and Joshua Welsch and Blasco Morozzo della Rocca and Alessandro Desideri and Mattia Falconi and Laurent Calcul and Bill J. Baker and Paola Fiorani},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141832903&doi=10.3390%2fcells11213486&partnerID=40&md5=fe87204e7bfe07fad1de1ffcbe2372e1},
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year = {2022},
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journal = {Cells},
volume = {11},
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Roglia, Valentina; Potestà, Marina; Minchella, Alessandra; Bruno, Stefania Paola; Bernardini, Roberta; Lettieri-Barbato, Daniele; Iacovelli, Federico; Gismondi, Angelo; Aquilano, Katia; Canini, Antonella; Muleo, Rosario; Colizzi, Vittorio; Mattei, Maurizio; Minutolo, Antonella; Montesano, Carla
Exogenous miRNAs from Moringa oleifera Lam. recover a dysregulated lipid metabolism Journal Article
In: Frontiers in Molecular Biosciences, vol. 9, 2022, (Cited by: 7; All Open Access, Gold Open Access).
@article{Roglia2022,
title = {Exogenous miRNAs from Moringa oleifera Lam. recover a dysregulated lipid metabolism},
author = {Valentina Roglia and Marina Potestà and Alessandra Minchella and Stefania Paola Bruno and Roberta Bernardini and Daniele Lettieri-Barbato and Federico Iacovelli and Angelo Gismondi and Katia Aquilano and Antonella Canini and Rosario Muleo and Vittorio Colizzi and Maurizio Mattei and Antonella Minutolo and Carla Montesano},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85143298547&doi=10.3389%2ffmolb.2022.1012359&partnerID=40&md5=9ee1bc1c2d6432d0e9914c28c550f627},
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journal = {Frontiers in Molecular Biosciences},
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2021
Romeo, Alice; Falconi, Mattia; Desideri, Alessandro; Iacovelli, Federico
Reconstructing the free energy profiles describing the switching mechanism of a ph-dependent dna nanodevice from abmd simulations Journal Article
In: Applied Sciences (Switzerland), vol. 11, no 9, 2021, (Cited by: 1; All Open Access, Gold Open Access).
@article{Romeo2021,
title = {Reconstructing the free energy profiles describing the switching mechanism of a ph-dependent dna nanodevice from abmd simulations},
author = {Alice Romeo and Mattia Falconi and Alessandro Desideri and Federico Iacovelli},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105778183&doi=10.3390%2fapp11094052&partnerID=40&md5=83996ec1463bb794f901820887ce514a},
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year = {2021},
date = {2021-01-01},
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volume = {11},
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Campione, Elena; Lanna, Caterina; Cosio, Terenzio; Rosa, Luigi; Conte, Maria Pia; Iacovelli, Federico; Romeo, Alice; Falconi, Mattia; Vecchio, Claudia Del; Franchin, Elisa; Lia, Maria Stella; Minieri, Marilena; Chiaramonte, Carlo; Ciotti, Marco; Nuccetelli, Marzia; Terrinoni, Alessandro; Iannuzzi, Ilaria; Coppeta, Luca; Magrini, Andrea; Bernardini, Sergio; Sabatini, Stefano; Rosapepe, Felice; Bartoletti, Pier Luigi; Moricca, Nicola; Lorenzo, Andrea Di; Andreoni, Massimo; Sarmati, Loredana; Miani, Alessandro; Piscitelli, Prisco; Squillaci, Ettore; Valenti, Piera; Bianchi, Luca
Lactoferrin as antiviral treatment in COVID-19 management: Preliminary evidence Journal Article
In: International Journal of Environmental Research and Public Health, vol. 18, no 20, 2021, (Cited by: 48; All Open Access, Gold Open Access, Green Open Access).
@article{Campione2021,
title = {Lactoferrin as antiviral treatment in COVID-19 management: Preliminary evidence},
author = {Elena Campione and Caterina Lanna and Terenzio Cosio and Luigi Rosa and Maria Pia Conte and Federico Iacovelli and Alice Romeo and Mattia Falconi and Claudia Del Vecchio and Elisa Franchin and Maria Stella Lia and Marilena Minieri and Carlo Chiaramonte and Marco Ciotti and Marzia Nuccetelli and Alessandro Terrinoni and Ilaria Iannuzzi and Luca Coppeta and Andrea Magrini and Sergio Bernardini and Stefano Sabatini and Felice Rosapepe and Pier Luigi Bartoletti and Nicola Moricca and Andrea Di Lorenzo and Massimo Andreoni and Loredana Sarmati and Alessandro Miani and Prisco Piscitelli and Ettore Squillaci and Piera Valenti and Luca Bianchi},
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Soren, Bini Chhetri; Dasari, Jagadish Babu; Ottaviani, Alessio; Messina, Beatrice; Andreotti, Giada; Romeo, Alice; Iacovelli, Federico; Falconi, Mattia; Desideri, Alessandro; Fiorani, Paola
In vitro and in silico characterization of an antimalarial compound with antitumor activity targeting human DNA topoisomerase IB Journal Article
In: International Journal of Molecular Sciences, vol. 22, no 14, 2021, (Cited by: 5; All Open Access, Gold Open Access).
@article{Soren2021,
title = {In vitro and in silico characterization of an antimalarial compound with antitumor activity targeting human DNA topoisomerase IB},
author = {Bini Chhetri Soren and Jagadish Babu Dasari and Alessio Ottaviani and Beatrice Messina and Giada Andreotti and Alice Romeo and Federico Iacovelli and Mattia Falconi and Alessandro Desideri and Paola Fiorani},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109503047&doi=10.3390%2fijms22147455&partnerID=40&md5=f471439670a12c1f1185eb3fb094c086},
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Campione, Elena; Lanna, Caterina; Cosio, Terenzio; Rosa, Luigi; Conte, Maria Pia; Iacovelli, Federico; Romeo, Alice; Falconi, Mattia; Vecchio, Claudia Del; Franchin, Elisa; Lia, Maria Stella; Minieri, Marilena; Chiaramonte, Carlo; Ciotti, Marco; Nuccetelli, Marzia; Terrinoni, Alessandro; Iannuzzi, Ilaria; Coppeda, Luca; Magrini, Andrea; Bernardini, Sergio; Sabatini, Stefano; Rosapepe, Felice; Bartoletti, Pier Luigi; Moricca, Nicola; Lorenzo, Andrea Di; Andreoni, Massimo; Sarmati, Loredana; Miani, Alessandro; Piscitelli, Prisco; Valenti, Piera; Bianchi, Luca
Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences Journal Article
In: Frontiers in Pharmacology, vol. 12, 2021, (Cited by: 62; All Open Access, Gold Open Access, Green Open Access).
@article{Campione2021b,
title = {Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences},
author = {Elena Campione and Caterina Lanna and Terenzio Cosio and Luigi Rosa and Maria Pia Conte and Federico Iacovelli and Alice Romeo and Mattia Falconi and Claudia Del Vecchio and Elisa Franchin and Maria Stella Lia and Marilena Minieri and Carlo Chiaramonte and Marco Ciotti and Marzia Nuccetelli and Alessandro Terrinoni and Ilaria Iannuzzi and Luca Coppeda and Andrea Magrini and Sergio Bernardini and Stefano Sabatini and Felice Rosapepe and Pier Luigi Bartoletti and Nicola Moricca and Andrea Di Lorenzo and Massimo Andreoni and Loredana Sarmati and Alessandro Miani and Prisco Piscitelli and Piera Valenti and Luca Bianchi},
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year = {2021},
date = {2021-01-01},
journal = {Frontiers in Pharmacology},
volume = {12},
note = {Cited by: 62; All Open Access, Gold Open Access, Green Open Access},
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Minutolo, Antonella; Potestà, Marina; Roglia, Valentina; Cirilli, Marco; Iacovelli, Federico; Cerva, Carlotta; Fokam, Joseph; Desideri, Alessandro; Andreoni, Massimo; Grelli, Sandro; Colizzi, Vittorio; Muleo, Rosario; Montesano, Carla
Plant microRNAs from Moringa oleifera Regulate Immune Response and HIV Infection Journal Article
In: Frontiers in Pharmacology, vol. 11, 2021, (Cited by: 16; All Open Access, Gold Open Access, Green Open Access).
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title = {Plant microRNAs from Moringa oleifera Regulate Immune Response and HIV Infection},
author = {Antonella Minutolo and Marina Potestà and Valentina Roglia and Marco Cirilli and Federico Iacovelli and Carlotta Cerva and Joseph Fokam and Alessandro Desideri and Massimo Andreoni and Sandro Grelli and Vittorio Colizzi and Rosario Muleo and Carla Montesano},
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Silva, Monize M. Da; Ribeiro, Gabriel H.; Camargo, Mariana S. De; Ferreira, Antônio G.; Ribeiro, Leandro; Barbosa, Marília I. F.; Deflon, Victor M.; Castelli, Silvia; Desideri, Alessandro; Corrêa, Rodrigo S.; Ribeiro, Arthur B.; Nicolella, Heloiza D.; Ozelin, Saulo D.; Tavares, Denise C.; Batista, Alzir A.
Ruthenium(II) Diphosphine Complexes with Mercapto Ligands That Inhibit Topoisomerase IB and Suppress Tumor Growth in Vivo Journal Article
In: Inorganic Chemistry, vol. 60, no 18, pp. 14174 – 14189, 2021, (Cited by: 9).
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Lallo, Gustavo Di; Falconi, Mattia; Iacovelli, Federico; Frezza, Domenico; D’Addabbo, Pietro
Analysis of four new enterococcus faecalis phages and modeling of a hyaluronidase catalytic domain from saphexavirus Journal Article
In: PHAGE: Therapy, Applications, and Research, vol. 2, no 3, pp. 131 – 141, 2021, (Cited by: 3; All Open Access, Gold Open Access).
@article{DiLallo2021131,
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Martínez-Labarga, Cristina; Carbone, Raoul; Ridolfi, Valeria; Parrino, Marta; Vitali, Sabrina; Bravi, Luigi; Rickards, Olga; Falconi, Mattia
Craniofacial reconstruction of Raphael Sanzio from Urbino: Face and features of a “mortal god” Journal Article
In: Digital Applications in Archaeology and Cultural Heritage, vol. 22, 2021, (Cited by: 2).
@article{Martínez-Labarga2021,
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Ottaviani, Alessio; Iacovelli, Federico; Fiorani, Paola; Desideri, Alessandro
Natural compounds as therapeutic agents: The case of human topoisomerase ib Journal Article
In: International Journal of Molecular Sciences, vol. 22, no 8, 2021, (Cited by: 14; All Open Access, Gold Open Access).
@article{Ottaviani2021,
title = {Natural compounds as therapeutic agents: The case of human topoisomerase ib},
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Lallo, Gustavo Di; Falconi, Mattia; Iacovelli, Federico; Frezza, Domenico; D’Addabbo, Pietro
Analysis of four new enterococcus faecalis phages and modeling of a hyaluronidase catalytic domain from saphexavirus Journal Article
In: PHAGE: Therapy, Applications, and Research, vol. 2, no 3, pp. 131 – 141, 2021, (Cited by: 3; All Open Access, Gold Open Access).
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Caporali, Sabrina; Didona, Biagio; Paradisi, Mauro; Mauriello, Alessandro; Campione, Elena; Falconi, Mattia; Iacovelli, Federico; Minieri, Marilena; Pieri, Massimo; Bernardini, Sergio; Terrinoni, Alessandro
Post zygotic, somatic, deletion in KERATIN 1 V1 domain generates structural alteration of the K1/K10 dimer, producing a monolateral palmar epidermolytic nevus Journal Article
In: International Journal of Molecular Sciences, vol. 22, no 13, 2021, (Cited by: 1; All Open Access, Gold Open Access).
@article{Caporali2021,
title = {Post zygotic, somatic, deletion in KERATIN 1 V1 domain generates structural alteration of the K1/K10 dimer, producing a monolateral palmar epidermolytic nevus},
author = {Sabrina Caporali and Biagio Didona and Mauro Paradisi and Alessandro Mauriello and Elena Campione and Mattia Falconi and Federico Iacovelli and Marilena Minieri and Massimo Pieri and Sergio Bernardini and Alessandro Terrinoni},
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Frigerio, Barbara; Luison, Elena; Desideri, Alessandro; Iacovelli, Federico; Camisaschi, Chiara; Seregni, Ettore C.; Canevari, Silvana; Figini, Mariangela
Validity of anti-psma scfvd2b as a theranostic tool: A narrative-focused review Journal Article
In: Biomedicines, vol. 9, no 12, 2021, (Cited by: 4; All Open Access, Gold Open Access, Green Open Access).
@article{Frigerio2021,
title = {Validity of anti-psma scfvd2b as a theranostic tool: A narrative-focused review},
author = {Barbara Frigerio and Elena Luison and Alessandro Desideri and Federico Iacovelli and Chiara Camisaschi and Ettore C. Seregni and Silvana Canevari and Mariangela Figini},
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Raniolo, Sofia; Unida, Valeria; Vindigni, Giulia; Stolfi, Carmine; Iacovelli, Federico; Desideri, Alessandro; Biocca, Silvia
Combined and selective miR-21 silencing and doxorubicin delivery in cancer cells using tailored DNA nanostructures Journal Article
In: Cell Death and Disease, vol. 12, no 1, 2021, (Cited by: 22; All Open Access, Gold Open Access, Green Open Access).
@article{Raniolo2021,
title = {Combined and selective miR-21 silencing and doxorubicin delivery in cancer cells using tailored DNA nanostructures},
author = {Sofia Raniolo and Valeria Unida and Giulia Vindigni and Carmine Stolfi and Federico Iacovelli and Alessandro Desideri and Silvia Biocca},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098852477&doi=10.1038%2fs41419-020-03339-3&partnerID=40&md5=2b52d4e061b9bb964804515eab656e96},
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Napoli, Alessandro; Iacovelli, Federico; Fagliarone, Claudia; Pascarella, Gianmarco; Falconi, Mattia; Billi, Daniela
Genome-Wide Identification and Bioinformatics Characterization of Superoxide Dismutases in the Desiccation-Tolerant Cyanobacterium Chroococcidiopsis sp. CCMEE 029 Journal Article
In: Frontiers in Microbiology, vol. 12, 2021, (Cited by: 6; All Open Access, Gold Open Access, Green Open Access).
@article{Napoli2021,
title = {Genome-Wide Identification and Bioinformatics Characterization of Superoxide Dismutases in the Desiccation-Tolerant Cyanobacterium Chroococcidiopsis sp. CCMEE 029},
author = {Alessandro Napoli and Federico Iacovelli and Claudia Fagliarone and Gianmarco Pascarella and Mattia Falconi and Daniela Billi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107604186&doi=10.3389%2ffmicb.2021.660050&partnerID=40&md5=5f1e23146458f9664c668b2a03bbaca7},
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Vindigni, Giulia; Raniolo, Sofia; Iacovelli, Federico; Unida, Valeria; Stolfi, Carmine; Desideri, Alessandro; Biocca, Silvia
AS1411 aptamer linked to DNA nanostructures diverts its traffic inside cancer cells and improves its therapeutic efficacy Journal Article
In: Pharmaceutics, vol. 13, no 10, 2021, (Cited by: 20; All Open Access, Gold Open Access, Green Open Access).
@article{Vindigni2021,
title = {AS1411 aptamer linked to DNA nanostructures diverts its traffic inside cancer cells and improves its therapeutic efficacy},
author = {Giulia Vindigni and Sofia Raniolo and Federico Iacovelli and Valeria Unida and Carmine Stolfi and Alessandro Desideri and Silvia Biocca},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117907115&doi=10.3390%2fpharmaceutics13101671&partnerID=40&md5=a90ae20687b1ad32b74e218089bcb7c1},
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2020
Pietrucci, Daniele; Teofani, Adelaide; Unida, Valeria; Cerroni, Rocco; Biocca, Silvia; Stefani, Alessandro; Desideri, Alessandro
Can gut microbiota be a good predictor for Parkinson’s disease? A machine learning approach Journal Article
In: Brain Sciences, vol. 10, no 4, 2020, (Cited by: 25; All Open Access, Gold Open Access, Green Open Access).
@article{Pietrucci2020,
title = {Can gut microbiota be a good predictor for Parkinson’s disease? A machine learning approach},
author = {Daniele Pietrucci and Adelaide Teofani and Valeria Unida and Rocco Cerroni and Silvia Biocca and Alessandro Stefani and Alessandro Desideri},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083777147&doi=10.3390%2fbrainsci10040242&partnerID=40&md5=77cad083159dc61e3046df32783489ea},
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Romeo, Alice; Iacovelli, Federico; Falconi, Mattia
Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential fusion inhibitors Journal Article
In: Virus Research, vol. 286, 2020, (Cited by: 51; All Open Access, Green Open Access).
@article{Romeo2020,
title = {Targeting the SARS-CoV-2 spike glycoprotein prefusion conformation: virtual screening and molecular dynamics simulations applied to the identification of potential fusion inhibitors},
author = {Alice Romeo and Federico Iacovelli and Mattia Falconi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086774561&doi=10.1016%2fj.virusres.2020.198068&partnerID=40&md5=007950a06cd6ce167385810bec03da16},
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Silva, Monize M.; Camargo, Mariana S.; Castelli, Silvia; Grandis, Rone A.; Castellano, Eduardo E.; Deflon, Victor M.; Cominetti, Marcia R.; Desideri, Alessandro; Batista, Alzir A.
Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB Journal Article
In: Journal of the Brazilian Chemical Society, vol. 31, no 3, pp. 536 – 549, 2020, (Cited by: 8; All Open Access, Gold Open Access).
@article{daSilva2020536,
title = {Ruthenium(II)-mercapto Complexes with Anticancer Activity Interact with Topoisomerase IB},
author = {Monize M. Silva and Mariana S. Camargo and Silvia Castelli and Rone A. Grandis and Eduardo E. Castellano and Victor M. Deflon and Marcia R. Cominetti and Alessandro Desideri and Alzir A. Batista},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083674896&doi=10.21577%2f0103-5053.20190214&partnerID=40&md5=e82c5dc846d3b71ce9fc9299ec2bef3f},
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D’amico, Federico; Doldo, Elena; Pisano, Calogera; Scioli, Maria Giovanna; Centofanti, Federica; Proietti, Giulia; Falconi, Mattia; Sangiuolo, Federica; Ferlosio, Amedeo; Ruvolo, Giovanni; Orlandi, Augusto
Specific mirna and gene deregulation characterize the increased angiogenic remodeling of thoracic aneurysmatic aortopathy in marfan syndrome Journal Article
In: International Journal of Molecular Sciences, vol. 21, no 18, pp. 1 – 20, 2020, (Cited by: 13; All Open Access, Gold Open Access, Green Open Access).
@article{D’amico20201,
title = {Specific mirna and gene deregulation characterize the increased angiogenic remodeling of thoracic aneurysmatic aortopathy in marfan syndrome},
author = {Federico D’amico and Elena Doldo and Calogera Pisano and Maria Giovanna Scioli and Federica Centofanti and Giulia Proietti and Mattia Falconi and Federica Sangiuolo and Amedeo Ferlosio and Giovanni Ruvolo and Augusto Orlandi},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091144296&doi=10.3390%2fijms21186886&partnerID=40&md5=2a42e827cd386cb28f8d977da9cf8e8c},
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Dasari, Jagadish Babu; Soren, Bini Chhetri; Ottaviani, Alessio; Tesauro, Cinzia; Marino, Simona; Messina, Beatrice; Fiorani, Paola
Swapping of The N-Terminal Domain of Human Topoisomerase 1B with the Corresponding Plasmodium Falciparum Counterpart Strongly Impairs Enzyme Activity Journal Article
In: Reports of Biochemistry and Molecular Biology, vol. 8, no 4, pp. 366 – 375, 2020, (Cited by: 0).
@article{Dasari2020366,
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Raniolo, Sofia; Iacovelli, Federico; Unida, Valeria; Desideri, Alessandro; Biocca, Silvia
In silico and in cell analysis of openable DNA nanocages for miRNA silencing Journal Article
In: International Journal of Molecular Sciences, vol. 21, no 1, 2020, (Cited by: 7; All Open Access, Gold Open Access).
@article{Raniolo2020,
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Lopes, Bruno Rafael Pereira; Costa, Mirian Feliciano; Ribeiro, Amanda Genova; Lima, Caroline Sprendel; Caruso, Icaro Putinhon; Araújo, Gabriela Campos; Kubo, Letícia Hiromi; Iacovelli, Federico; Falconi, Mattia; Desideri, Alessandro; Oliveira, Juliana; Regasini, Luis Octávio; Souza, Fátima Pereira; Toledo, Karina Alves; Silva, Tiago Francisco
Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion Journal Article
In: Virus Research, vol. 276, 2020, (Cited by: 42; All Open Access, Bronze Open Access, Green Open Access).
@article{Lopes2020,
title = {Quercetin pentaacetate inhibits in vitro human respiratory syncytial virus adhesion},
author = {Bruno Rafael Pereira Lopes and Mirian Feliciano Costa and Amanda Genova Ribeiro and Caroline Sprendel Lima and Icaro Putinhon Caruso and Gabriela Campos Araújo and Letícia Hiromi Kubo and Federico Iacovelli and Mattia Falconi and Alessandro Desideri and Juliana Oliveira and Luis Octávio Regasini and Fátima Pereira Souza and Karina Alves Toledo and Tiago Francisco Silva},
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Turchi, Riccardo; Tortolici, Flavia; Guidobaldi, Giulio; Iacovelli, Federico; Falconi, Mattia; Rufini, Stefano; Faraonio, Raffaella; Casagrande, Viviana; Federici, Massimo; Angelis, Lorenzo De; Carotti, Simone; Francesconi, Maria; Zingariello, Maria; Morini, Sergio; Bernardini, Roberta; Mattei, Maurizio; Rosa, Piergiorgio La; Piemonte, Fiorella; Lettieri-Barbato, Daniele; Aquilano, Katia
Correction: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue (Cell Death & Disease, (2020), 11, 1, (51), 10.1038/s41419-020-2253-2) Journal Article
In: Cell Death and Disease, vol. 11, no 3, 2020, (Cited by: 4; All Open Access, Gold Open Access, Green Open Access).
@article{Turchi2020,
title = {Correction: Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue (Cell Death & Disease, (2020), 11, 1, (51), 10.1038/s41419-020-2253-2)},
author = {Riccardo Turchi and Flavia Tortolici and Giulio Guidobaldi and Federico Iacovelli and Mattia Falconi and Stefano Rufini and Raffaella Faraonio and Viviana Casagrande and Massimo Federici and Lorenzo De Angelis and Simone Carotti and Maria Francesconi and Maria Zingariello and Sergio Morini and Roberta Bernardini and Maurizio Mattei and Piergiorgio La Rosa and Fiorella Piemonte and Daniele Lettieri-Barbato and Katia Aquilano},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081173671&doi=10.1038%2fs41419-020-2347-x&partnerID=40&md5=fa5b09a7df62b686a578873cd1c040dd},
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number = {3},
note = {Cited by: 4; All Open Access, Gold Open Access, Green Open Access},
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Tortosa, Valentina; Patti, Maria Carmela Bonaccorsi Di; Iacovelli, Federico; Pasquadibisceglie, Andrea; Falconi, Mattia; Musci, Giovanni; Polticelli, Fabio
Dynamical behavior of the human ferroportin homologue from bdellovibrio bacteriovorus: Insight into the ligand recognition mechanism Journal Article
In: International Journal of Molecular Sciences, vol. 21, no 18, pp. 1 – 13, 2020, (Cited by: 4; All Open Access, Gold Open Access).
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title = {Dynamical behavior of the human ferroportin homologue from bdellovibrio bacteriovorus: Insight into the ligand recognition mechanism},
author = {Valentina Tortosa and Maria Carmela Bonaccorsi Di Patti and Federico Iacovelli and Andrea Pasquadibisceglie and Mattia Falconi and Giovanni Musci and Fabio Polticelli},
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Soren, Bini Chhetri; Dasari, Jagadish Babu; Ottaviani, Alessio; Iacovelli, Federico; Fiorani, Paola
Topoisomerase IB: a relaxing enzyme for stressed DNA Journal Article
In: Cancer Drug Resistance, vol. 3, no 1, pp. 18 – 25, 2020, (Cited by: 15; All Open Access, Gold Open Access).
@article{Soren202018,
title = {Topoisomerase IB: a relaxing enzyme for stressed DNA},
author = {Bini Chhetri Soren and Jagadish Babu Dasari and Alessio Ottaviani and Federico Iacovelli and Paola Fiorani},
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